TfR1 Receptor — De Novo VHH Candidates

Two de novo VHH designs docked on the intact human transferrin receptor (PDB 1SUV: TfR1 homodimer + iron-loaded transferrin). Both engage the accessible apical epitope clear of the receptor body, in poses validated across two independent structure predictors. Rotate and zoom with your mouse.

TfR1 dimer
Apical domain (target)
Transferrin
De novo VHH
VHH paratope